In fact it has been indicated that COX-2 is concerned with inflammatory PG production in several inflammatory diseases.

• 环氧合酶(Cyclooxygenase，COX)是以花生四烯酸(Arachidonic Acid，AA)为底物合成前列腺素(Prostaglandins，PGs)的关键酶和首要限速酶，已证实存在两种亚型：COX-1和COX-2。