In addition to immunopathogenesis, interaction between virus and vascular endothelia cells (VEC) which result in dysfunction of VEC may mediate DHF/DSS.

• DHF/DSS的主要临床表现是血管通透性增加引起的出血和休克,除免疫机制外,病毒颗粒本身可通过直接或间接途径作用于血管内皮细胞(vascular endothelial cells, VEC),影响其功能,进而介导DHF/DSS的发生。