Hydrogen peroxide(H2O2) can reversible deactivate PTEN by forming a disulfide bond between the active -site of Cys124,Cys71.H2O2 can also control PTEN by Egr-1 in transcriptional level.

• 过氧化氢(H2O2)通过在活性位点半胱氨酸残基Cys124与Cys71之间形成二硫键,可逆地氧化灭活PTEN。 H2O2还可通过Egr-1在转录水平调控PTEN。