Howeer, mutant ABCG2 can be less efficient at pushing gefitinib out of cells in the intestine, the researchers noted. A buildup of drug within these cells can cause diarrhea.

• 研究人员指出，突变的ABCG2降低了肠道细胞“泵出”的功能，使得细胞内的药物逐渐累积从而导致腹泻。