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- The massive researches on histone methyltransferase and effector proteins in recent years have increased our understanding of H3K4 methylation. 随着对组蛋白甲基化转移酶及相关作用蛋白研究的深入,人们对组蛋白H3第4赖氨酸的甲基化的功能也有了更深的了解。
- histone methyltransferase 组蛋白甲基转移酶
- A Novel Member SET07 from Histone Methyltransferases(HMT) Family 一个新的HMT家族成员SET07的理化性质及其功能
- Keywords DNA methyltransferases;Histone methyltransferase;Methylation;Epigenetics;Colon cancer;Reverse transcription-polymerase chain reaction; DNA甲基化酶;组蛋白甲基化酶;甲基化;表观遗传学;结肠癌;逆转录聚合酶链式反应;
- The histone code will not be easy to crack. 组织蛋白的密码不是那么容易破解的。
- Keywords histone methylase;histone methyltransferases;heterochromatin protein 1;gene expression regulation; 组蛋白甲基化;组蛋白甲基转移酶;异染色质蛋白1;基因表达调控;
- A nucleoprotein whose protein component is a histone. 核组蛋白蛋白成分是组蛋白的核蛋白
- A nucleoprotein whose protein componentis a histone. 核组蛋白蛋白成分是组蛋白的核蛋白。
- Some of this damage can be repaired by the DNA methyltransferase MGMT. 这类损伤中有一部分可被DNA甲基转移酶MGMT所修复。
- Study on histone acetylation in myoblast cultures of DMD chicken embryo. 进行性肌营养不良鸡胚成肌细胞组蛋白的乙酰化研究。
- Histone acetylation/deacetylation is closely related to the regulation of gene. 组蛋白乙酰化/去乙酰化与基因调控密切相关。
- Histone lysine methylation plays a key role in epigenetic regulation. 摘要组蛋白赖氨酸的甲基化在表观遗传调控中起着关键作用。
- Histone modifications are implicated in influencing gene expression. 组蛋白修饰与影响基因表达有关。
- Histone deacetylase inhibitors had been used to treat cancer and leukemia. 组蛋白去乙酰化酶抑制剂已经越来越多的被用于治疗肿瘤和白血病。
- histone methyltransferases 组蛋白甲基转移酶
- In vitro activity assays confirmed that recombinant OsSET3 was a functional H3K9 methyltransferase while OsSET2 and OsSET4 were not. 利用大肠杆菌表达的OsSET2、OsSET3和OsSET4重组蛋白进行的体外活性检测实验证明OsSET3具有组蛋白H3K9的甲基转移酶活性,而OsSET2和OsSET4不具有该活性。
- Objective To explore the role of protein expression of DNA methyltransferase 1(DNMT1) in lung adenocarcinoma carcinogenesis and prognosis. 目的检测肺腺癌中DNA甲基转移酶1(DNMT1)蛋白水平的表达,探讨其在肺腺癌发生中的作用及其预后价值。
- The chromatin remodeling and histone acetylation were associated with transcription activation. 真核基因活化与染色质的重建及组蛋白的乙酰化相关。
- They found that HP1 proteins, which bind to methylated histones, also interact with the DNA methyltransferase, DNMT1, to stimulate its DNA methylation actiity. 他们还发现与甲基化组蛋白相结合的Hp1蛋白和DNA甲基转移酶(DNMT)即DNMT1之间也存在相互作用,它可激发DNA甲基化活性。
- Objective:To detect the expression of O6-methylguanine-DNA methyltransferase (MGMT),and it s effect of promoter hypermethylation on tumorigenesis and progression. 目的:检测大肠癌组织中O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)的表达情况及其在肿瘤发生发展中的作用和临床意义。