Hammerhead ribozyme can cleave the target NHE 1 mRNA specifically, reduce the expression of NHE 1 mRNA and induce intracellular acidosis.

• 所设计的锤头状核酶可对NHE 1mRNA进行特异性切割 ,减少其表达 ,使其活性下降 ,从而诱导细胞酸化。