HCC is closely related to some carcinogens such as hepatitis B virus infection, AFB1, pollution of drinking water, nutrition, alcohol consumption and some trace elements.

• HCC的发生不仅与肝炎病毒感染，黄曲霉素（AFB1）和饮水污染、营养、饮酒有关，也与微量元素尤其是硒的改变存在某种微妙关系。