HAV normally is not cytopathic in infected cells, and its growth is a lengthy, inefficient process with low virus yield, which usually takes 3 to 4 weeks.

• 甲肝病毒一般不引起宿主细胞病变，生长缓慢，周期长，最佳产毒培养时间需3至4周，病毒产量不高。