Guided by prodrug strategy, 20-O-linked succinate-based camptothecin ester derivatives were firstly synthesized and their structures were characterized by LC/MS, NMR and element analysis.

• 我们采取喜树碱前药设计的思路，首次合成了一系列20位酯化的琥珀酸喜树碱衍生物，利用各种手段确证了化合物的结构。