Furthermore, we successfully induced metastatic behaviors of RasV12 cells by blocking the lysosomal degradation pathway with anti-malarial drug chloroquine or monensin.

• 为了进一步探讨内吞运输途径和肿瘤转移的关系，我们分别利用抗虐疾药物氯喹和莫能菌素阻断溶酶体的降解功能，成功地在RasV12肿瘤细胞中模拟了肿瘤转移的表型。