Furthermore, radioactive labeling followed by subcellular fractionation showed that a significant portion of the newly synthesized GRP78 is localized to the mitochondria in cells under UPR.

• 利用放射线标示新合成蛋白质并接著进行胞器分离实验，结果显示当细胞遭遇内质网逆境，新合成的GRP78会目标导向进入粒线体。