For women who had never used estrogen therapy, bilateral oophorectomy before age 50 years was associated with an increased risk for all-cause mortality, CHD, and stroke.

• 对从未使用雌性激素疗法的女性，50岁以前接受双侧卵巢切除术，与所有原因的死亡率、CHD与中风风险增加有关。