Firstly, when RNA polymerase is moving on a DNA template, transcription can result in negative supercoiling behind the polymerase, thus facilitating Z-DNA conformation at permissive regions.

 
  • 形成Z-DNA的原因有很多:首先,转录过程中,移动的RNA聚合酶在模板DNA的5'端产生负超螺旋扭曲力,导致Z-DNA的形成;
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