Finally, 2- alkylthio-4-arylsulfanilamidepyrimidine-5-hydroxamates as a novel kind of MMP inhibitors were obtained.All compouds were tested in vitro for the inhibition of MMP-16.

• 本论文的第二章便是通过对反应路线的摸索和设计，最终合成出一类新型的2-烷巯基-4-芳香磺胺嘧啶-5-异羟肟酸类抑制剂。