FISH on lymphocytes using human chromosome 21 probes prepared by UP PCR gives bright hybridization signals and correct numbers of chromosome 21 in more than 98.4% of interphase nuclei and 99.6% of metaphases, respectively.

• 此法制备的人21号染色体FISH探针,特异性强,杂交信号明亮,21号染色体的检出率高。 该法稳定简便。