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- No mutation was found in exon 5, 8 of FHIT gene. 而正常人FHIT基因外显子5和8无1例缺失；
- The FHIT gene change is a relatively late event in CINs. FHIT基因的改变是CIN发生过程中的较晚期事件;
- The whole FHIT gene was found deleted in an EC cell line, EC8733. 在食管癌细胞系EC8733中发现了FHIT全基因的丢失。
- Hypermethylation of CpG island in the promoter region of FHIT gene is a early and common alterration. 子宫内膜癌组织中存在FHIT基因启动子区域CpG岛的甲基化 ,CpG岛的甲基化与临床病理特征之间无相关性。
- No point mutation of FHIT gene exon 5 and exon 8 was found in 30 cases of tumor tissues. 所有胃癌组织标本均未检测到外显子5,8的点突变。
- Objective: To study the aberrant transcription of FHIT gene in CRC during the induction by DMH in rats. 结论：FHIT基因的异常转录与二甲肼诱导大鼠大肠癌的发生、发展有关；
- Conclusion The alteration of FHIT protein in ESCC was not necessary coincident with FHIT gene change in genomic level. 结论食管癌中FHIT癌蛋白表达的变化与基因改变的变化并非一致。
- Conclusion FHIT gene expressing deletion was common in lung squamous carcinoma and was apparent correlative with smoking. 结论FHIT表达缺失是肺鳞癌的常见事件,而且与吸烟明显相关。
- Objective To explore the relation between HPV infection and lung cancer in female nonsmoker, and to investigate its relationship with LOH of FHIT gene. 摘要目的探讨人乳头瘤病毒(HPV)感染与非吸烟女性肺癌的相关性，以及HPV感染对脆性组氨酸三联体(FHIT)基因杂合性丢失的影响。
- Objective: To investigate the abnormal expression and alteration of MMP10 and FHIT gene on the carcinogenesis and development of esophageal cancer. 摘要目的：探讨基质金属蛋白酶10(MMP10)、脆性组氨酸三联体(FHIT)基因在食管癌中的异常表达及二者对其发生、发展的作用。
- Results: The total homozygous deletions rate of FHIT gene exon 5 and exon 8 were 23.33% and 0% in normal tissues (P=0.01). 结果：胃癌组织中FHIT基因外显子5、8总纯合性缺失率为23.;33%25，正常组织无一例缺失(P=0
- There exist hypermethylation, abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer. 肝癌中存在FHIT基因高甲基化、转录异常、FHIT蛋白表达下降。
- The alternations of FHIT gene correlate with several clinic pathological indicators such as progression, invasion, relapse rate, and survival rate of liver cancer. FHIT基因的改变与肝癌的演进、侵袭性、复发率和生存率等多项临床病理指标有关。
- Objective:To detect allelic deletion and mutation of FHIT gene in gastric cancer, and to analyze the role of the abnormalities in the carcinogenesis of gastric cancer. 目的:检测脆性组氨酸三联体基因在胃癌组织中等位基因缺失和突变情况,分析该异常在胃癌发生中的作用。
- Microsatellite analysis showed that both loss of heterozygosity and microsatellite instability of FHIT gene existed in laryngeal carcinoma and the former was more common. 微卫星多态分析表明，FHIT基因在喉癌中既存在杂合性丢失，又存在微卫星不稳定现象，但以前者为主。
- The discovery of D3S1300 locus with highly frequent LOH suggested that FHIT gene located in this region might act as a candidate tumor suppressor gene in the development of colorectal carcinoma. 高频LOH位点D3S130 0的发现 ;提示 3p14.;2附近区域的FHIT基因可能作为肿瘤抑制基因在结直肠癌的发生发展中发挥作用。
- CpG island methylation of FHIT was detected in 31.13% of the plasma samples, and in 53.33% of the tissue samples. The total concordant rate of methylation status between plasma and tissue samples in FHIT gene was 80.00%. 结果在宫颈癌患者血浆和组织中;FHIT基因5′端CpG岛甲基化率为30.;46%25和53
- Methylation of the FHIT gene and it's relationship to tumors FHIT基因甲基化及其与肿瘤的关系
- Keywords ] FHIT gene;Esophageal;carcinoma;Histochemistry; FHIT基因;食管癌;免疫组织化学;
- Keywords FHIT gene;carcinoma of colon;total RNA;exon;open reading frame; 关键词FHIT基因;结肠癌;总RNA;外显子;开放阅读框架;
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