Experimental hepatic fibrosis rat models induced by CCl_4 were prepared. In situ hybridization and immunohistochemistry methods were respectively used to detect MMP-13,MMP-2,MT-MMP2 mRNA and the related antigens in liver.

• 建立大鼠实验性四氯化碳中毒性肝纤维化模型,采用核酸原位杂交和免疫组化法检测实验性肝纤维化自然逆转过程中MMP-13、MMP-2、MT-MMP2的来源细胞、时序和量的变化。