Even making a mouse hybridoma is tricky: B cells from the spleen of an immunized mouse, which normally died out in culture dishes, must be fused with cancerous white blood cells called myelomas.

• 制造小鼠的杂交瘤还有一个很难解决的问题：从免疫过的细胞脾脏中取到的B细胞，它在培养器皿中会逐渐死亡，如果一种叫骨髓瘤的白血细胞就保险得多。