Ets-1 interacted selectively with the ~ -1350GGAA~ -1347 Ets element in the P21WAF1/CIP1 promoter. Mutation of this element reduced basal and Ets-1-inducible P21WAF1/CIP1 promoter-dependent expression.

• Ets-1选择性地作用于P21WAF1/CIP1启动子中-1350GGAA-1347Ets元件,该元件的序列突变可降低基础表达和Ets-1诱导的P21WAF1/CIP1启动子依赖的表达。