EPF was first described as immunity suppression factor and growth factor that appeared in serum of pregnant women during their early trimester and was necessary in early embryonic development.

• 后来的研究发现在人恶性肿瘤(膀胱癌、黑色素瘤、绒癌和恶性葡萄胎)患者的血清中也能检测到EPF，动物实验发现EPF与肿瘤的发生发展有关。