E2 increased the apoptosis rates of splenic cells in the highconcentrations, which might be due to the increase expression levels of Fas, FasL mRNA.

• 高浓度E2致脾细胞凋亡,与上调凋亡促进基因Fas、FasL基因表达有关,低浓度E2可能逆转去势小鼠脾细胞凋亡。