During the long-term evolution an integrated regulation system, which is highly conserved in eukaryotes from yeast to homo sapient, has developed to regulate copper transportation and homeostasis.

• 在长期进化过程中真核生物形成了一套完整的铜转运和稳态调节系统，从酵母到灵长类的各种生物都具有高度同源性的调控组件。