During the induced rat lung squamous cell carcinogenesis,deletion of the p16 INK4a gene plays an important role in early stage,the biology activity of p19 ARF is stronger than that of p16 INK4a .

• 在诱发性大鼠肺鳞癌的发生发展中 ,p16 INK4a基因的缺失可能在早期已起作用 ,p19ARF的生物学活性可能强于p16 INK4a。