Due to the hydrolysis of halogenoalkylamino and reaction of halogenoalkyl and pyrrole and polypyrrole, it was impossible to obtain the desired substituted porphyrins using Adler method which used propanoic acid as solvent under reflux condition.

• 由于卤代烷基氨基容易水解且能与吡咯和吡咯的聚合物发生反应，所以用Adler方法不能得到目标卟啉。