Double therapy with MTX and LEF worked earlier and afforded more benefits for patients who have RF?100 IU/mL and X ray classification above phase I comparatively compared with triple-therapy of MTX,CQ and SSZ.

• MTX-LEF二联组起效早,对血清RF>100IU/mL且X线分期?I期患者疗效优于MTX-CQ-SSZ三联组。