Differential expression of the two isoforms not only might contribute to insulin resistance in type 2 diabetes mellitus, but also play an important role in the pathogenesis of cancer.

• 这种差异不仅可能是导致胰岛素抵抗、2型糖尿病的重要原因，也会影响肿瘤细胞的生长、增殖、抗凋亡。