Deuterated perlolyrine was synthes ized starting from deuterated tryptophan via acid-catalyzed ring-closure, aromatisation and hydrolysis, with a yield of 11.6%and abundance of about 95%.

• 以色氨酸和氘水反应合成的氘标色氨酸为原料；经环化、氧化脱羧及水解等反应合成氘标川芎哚；产为11.；6%25；氘标总丰度约为90%25。