Depending on caspase activation, methadone overcomes doxorubicin resistance, multidrug resistance, and apoptosis resistance in leukemia cells through activation of mitochondria.

 
  • 依赖于半胱氨酸蛋白酶的激活,美沙酮通过激活线粒体克服了白血病细胞中的阿霉素耐药、多药耐药、和凋亡抑制。
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