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- dko小鼠的病理生理学表现与DMD极为相像,是DMD临床治疗研究的理想疾病动物模型。The pathophysiology of dko mouse was very similar to Duchenne muscular dystrophy (DMD), and dko mouse is an ideal animal model for study of DMD clinical therapy.
- 目的观察Duchenne型肌营养不良症模型DKO小鼠经骨髓间质干细胞(MSC)移植治疗后肌组织的超微结构改变情况。Objective To observe the ultrastructural changes in the muscular tissues of Duchenne muscular dystrophy mouse models with dystrophin/utrophin double-knockout (DKO) after transplantation of bone marrow-derived mesenchymal stem cells (MSCs).
- 目的 系统研究 C5 7鼠、mdx鼠、dystrophin/ utrophin基因双敲除 (dko)鼠运动功能、生化、病理等方面的差异 ,为假肥大型肌营养不良症 (DMD)的进一步研究提供可靠依据。Objective With a view to further experimental studies on Duchenne muscular dystrophy (DMD), we investigated the motor function,serum creatine kinase (CK) level and pathological characteristics of muscular tissue in C57,mdx,dystrophin/utrophin gene double knockout (dko)mice.
