DHT produced fast and transient increases in intracellular Ca~(2+) in a concentration-dependent manner, and quickly induced phosphorylation of ERK1/2 and JNK, but phosphorylation of p38 was inhibited in prostate cancer PC3 cells.

• DHT可以在一定范围内浓度依赖性地诱导PC3细胞[Ca~(2+)]i快速升高,而且也能快速诱导ERK1/2、JNK的磷酸化,但是对p38的磷酸化却表现为快速的抑制作用;