DHC could inhibit TIMP-1 expression in liver fibrosis tissues,thus attenuate the inhibition of matrix metalloproteinase-1,promote the degradation of extracellular matrix,which might be the possible mech- anism of DHC in anti-fibrosis of liver.

• 丹芍化纤胶囊能够抑制肝纤维化组织中,TIMP-1的表达,从而减弱了其对基质金属蛋白酶-1 (matrix metalloproteinase-1,MMP-1)的抑制作用,促进了细胞外基质的降解,可能是丹芍化纤胶囊抗肝纤维化作用的机制之一。