Cyanopyridine, intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.12% yield of 4-cyanopyridine.

• 以4-甲基吡啶为原料，在固定床反应器中通过含氧化钒的催化剂发生气固相接触氨氧化反应制备雷米封中间体4-氰基吡啶，4-甲基吡啶的转化率为99%25，4-氰基吡啶的选择性为88%25，收率为87.；12%25。