Currently,more and more nucleos(t) ide analogs are appearing as therapeutic options in the treatment of chronic hepatitis B(CHB).But prolonged therapy can develope antiviral resistance.

• 核苷(酸)类似物是目前临床上治疗乙型肝炎的重要药物,但应用过程中可出现乙型肝炎病毒的变异,从而发生耐药。