Conclutions:LTC 4 induces over expression of ET 1 mRNA and ET 1 release in 16 HBE and SMCS,which may be one of the important mechanism of LTs in airway inflammation and reconstraction in asthma.

• 结论 :LTC4 能上调 16 HBE及ASMC两种细胞ET 1mRNA的表达并刺激ET 1释放 ,这可能是白三烯致哮喘气道炎症及重塑的重要机制之一。