Concluson: Down-regulating TF expression and PCA of NB_4 and MR_2 cells by Realgar may be one of the mechanism of its improvement effect on DIC-related hemorrhage of APL patients.

• 结论 :下调NB4和MR2 细胞TF的表达并降低其PCA可能是雄黄改善APL患者弥散性血管内凝血 (DIC)早期出血症状的主要机制之一。