Conclusions: Both GDNF,MP and GDNF + MP groups might reduce [Ca 2+ ]i and CCW of injured spinal cord. The curative effect of MP for SCI preponderate over that of GDNF, the effect of MP could be enhanced by adding GDNF.

• :GDNF、mp及其联合应用均能降低脊髓组织 [Ca2 + ]i水平 ,减轻组织水肿 ,作用效果mp超过 GDNF,mp联合 GDNF治疗脊髓损伤能增强 mp的疗效。