Conclusions the NVAF patients have lower levels of MMP2, valsartan might inhibit the process of atrial structural remodeling by downregulation of MMP2 and upregulation of TIMP2 in NVAF patients.

• 结论 NVAF患者血清MMP2水平较高，缬沙坦组可降低血清中MMP 2，升高血清TIMP 2，提示缬沙坦可能通过改变MMP2和TIMP2参予心房重构。