Conclusions Wear particles in the osteolytic tissue can be obtained with strong base digestion and differential centrifugation, which is up to the demand of experimental study.

• 结论通过强碱消化及密度梯度离心提取、纯化假体周围骨溶解组织中磨损颗粒的方法可提供符合试验需要的金属颗粒。