Conclusions Intravenous administration of the MEK inhibitor U0126 inhibits MEK, ERK1, ERK2 and Elk-1 phosphorylation and activation induced by cerebral ischemia.

• 在缺血前20分钟注射U0126可抑制ERK1和ERK2的磷酸化，缺血后即刻或缺血20分钟后注射无抑制作用。