Conclusions Induction of osteoclast apoptosis and decrease of the cell number and inhibition of resorptive ability were the major mechanism for bone loss prevention effect of BM210955 in vitro.

• 结论诱导破骨细胞凋亡、降低破骨细胞生存数目并抑制细胞的骨吸收功能是BM210955延缓骨丢失、抑制骨吸收的主要机制之一。