Conclusion: The prognosis of melanoma was very poor, and combining therapies of operation, cryosurgery and immunotherapy should be advocated.

• 结论：口腔粘膜恶性黑色素瘤预后很差，包括手术、冷冻、免疫治疗等的综合治疗应是目前提倡的治疗方法。