Conclusion: The liver is an organ of primary resistance, and chemotherapy can induce MDR.The expression of P170 is one of the useful indexes of prognosis in PHC.

• 结论肝脏是原发性耐药器官，化疗可以诱发耐药的产生，P170的表达是原发性肝细胞癌的一个预后指标。