Conclusion: In the first IVF cycle of couples with unexplained infertility, splitting the sibling oocytes by IVF and ICSI can effectively minimize complete fertilization failure.

• 结论：不明原因不孕患者行首次IVF治疗时，采用部分卵母细胞常规受精、部分卵母细胞ICSI的方法，可降低完全受精失败风险。