Conclusion In vitro and in vivo antitumor activity has indicated that some derivatives appeared significantly more effective than topotecan in the H22 mouse liver tumoral model.

• 结论体内外抗肿瘤试验表明，对小鼠肝癌细胞H22模型，新合成的喜树碱衍生物4的抗肿瘤活性与拓扑替康相近，但毒性低于拓扑替康。