Con clu sion:In NB,the intrinsic multidrug resistance involves the combined effects of P-gp and MRP; age,metastasis,MRP expression and coexpression of P-gp and MRP has prognostic significance.

• 结论:NB原发性耐药与P-gp和MRP共同作用有关,年龄、转移、MRP表达及P-gp与MRP共表达与NB预后有关。