Changing the route of administration from oral or intravenous to intrathecal reduced toxicities by 50% overall, 33% more than with systemic drugs (P=.004).

• 将一般口服或静脉注射给药，改为脑脊髓内膜用药，可以使毒性降低50%25，比全身用药多33%25(P=0.；004)。