Somatic alterations within the oncogenome underlie the genesis and progression of most human tumors, by causing oncogene activation or tumor suppressor gene inactivation. 摘要大部分人类肿瘤是由基因组中的体细胞性改变所导致的癌基因激活或抑癌基因失活所引发的。
Cancer gene discoery has relied extensiely on analyzing tumors for gains and losses to reeal the location of oncogenes and tumor suppressor genes, respectiely. 癌症基因的发现在很大程度上依赖于对肿瘤的获得或丢失基因进行分析以定位癌基因和抑癌基因。
