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- Objective To investigate the role of proliferating cell nuclear antigen (PCNA) and cyclin dependent kinase 2 (CDK2) in inhibition of vascular smooth muscle cells (VSMCs) proliferation by gax gene. 目的 研究增殖细胞核抗原 (PCNA)和细胞周期蛋白依赖性激酶 2 (CDK2 )在gax基因抑制血管平滑肌细胞 (VSMC)增殖中的作用。
- Methods Expressions of cyclin E and cyclin dependent kinases 2(cdk2)in 38 cases of lung cancer and 6 cases of normal lung tissues were examined by immunohistochemistry. 方法 :应用免疫组化方法检测细胞周期蛋白E(cyclinE)和细胞周期蛋白依赖性激酶 2 (cdk2 )在 38例肺癌和 6例正常肺组织中的表达状况。
- cyclin dependent kinase 2 细胞周期素依赖性激酶2
- Purpose To investigate the roles of cyclin dependent kinase (cdk) 2 and cdk4 in the pathogenesis of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and their relation to PCNA. 目的:探讨细胞周期蛋白依赖性激酶cdk2和cdk4在前列腺增生(BPH)和前列腺癌(PC)的发生发展过程中作用及其与PCNA之间关系。
- Cell cycle is mainly regulated by cyclin, cyclin dependent kinase(CDK) and cyclin dependentkinase inhibitor (CDKI). 细胞周期主要是由细胞周期蛋白(cyclin),细胞周期蛋白依赖性激酶(CDKs)和CDK抑制蛋白(CDKI)来调控的。
- Protein serine theronine phosphatase inhibitor or cyclin dependent kinase( CDK) inhibitors could abolish the enhancement. 而蛋白丝氨酸苏氨酸磷酸酯酶抑制剂以及细胞周期蛋白依赖性激酶(DK)制剂可阻断该凋亡敏感性增强效应。
- Formation, activition and degradation of cyclin - dependent kinase(CDK) and cyclin complex are the main molecular foundation. 其中细胞周期素依赖性激酶(cyclin-dependent kinase,CDK)与细胞周期素(cyclin)复合体的形成、激活与失活是细胞周期调控的主要分子基础。
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年来发现细胞周期素(Cyclin)、细胞周期蛋白依赖激酶(Cyclin dependent kinase,CDK)和细胞周期蛋白依赖性激酶抑制因子(Cyclin dependent kinase inhibitor,CKI)在真核生物细胞周期调控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一种CKI,它可与多种cyclin/CDK复合物结合,引起细胞周期阻滞。
- It is well known that cell cycle in eukaryotic cells is controlled by various complexes composed of cyclin and cyclin dependent kinase (CDK). 真核细胞周期是受细胞周期蛋白(cyclin)和细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)组成的蛋白复合体调控。
- Objective:To study the expressions and the clinical significance of cyclin E and cyclin-dependent kinase 2 (cdk2) in bladder transitional cell carcinoma. 探讨细胞周期蛋白E(cyclinE)和细胞周期蛋白依赖性激酶 2 (cdk2 )与膀胱癌发病的关系及其临床意义。
- Objective:To investigate the expressions and significance of cyclin-dependent kinase 2 (CDK2) and heat shock protein 60 (HSP 60) in human cervical carcinoma. 目的 :研究人子宫颈癌组织中细胞周期蛋白依赖性激酶 (CDK) 2、热休克蛋白 (HSP) 60的表达状态 ,并探讨它们与宫颈癌的关系。
- Objective To investigate roles of cyclin dependent kinase 4 (CDK4) in nordihydroguaiaretic acid (NDGA) induced inhibitory effect on proliferation of human malignant glioma cells. 目的 探讨细胞周期蛋白依赖性蛋白激酶 4(CDK4)在去甲二氢愈创木酸 (NDGA)抑制人恶性胶质瘤细胞系SHG 44细胞增殖中的作用。
- Objective To explore the change rule of G protein coupled receptor kinase 2(GRK2) in the lung tissue of rats with acute lung injury(ALI) induced by lipopolysaccharide (LPS). 目的探讨脂多糖(LPS)诱导急性肺损伤(ALI)大鼠肺组织G蛋白偶联受体激酶2(GRK2)的变化规律。
- Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica. 目的 探讨细胞周期蛋白依赖激酶K4(CDK4)在石英致人胚肺成纤维细胞(2BS)恶性转化过程中所起的作用,为石英致癌机制提供理论依据。
- Yeast regulatory factor PHO85, which is a cyclin?dependent kinase (CDK), participates in the regulation of the cell cycle control and the expression of the acid phosphatase gene. 酵母调控因子PHO85是一个依赖于细胞周期蛋白(cyclin)的蛋白激酶(CDK),参与对细胞周期和酸性磷酸酯酶基因表达的调控。
- Objective: To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogensis、progression and recurrence of endometrial carcinoma . 目的:探讨PTEN、CDK4蛋白表达与子宫内膜癌的发生、发展及复发的关系。
- Methods Janus kinase 2 selective inhibitor AG490 was used to inhibit the activation of STAT3 signaling pathway. Matrigel-coated transwell was employed to estimate the invasiveness of BGG-823 cells. 方法 应用JAK2激酶抑制剂AG4 90处理胃癌BGC 82 3细胞 ,Matrigel肿瘤体外侵袭模型检测肿瘤细胞侵袭 ;
- Aim To explore the possible role of p21, cyclin E and cyclin-dependent kinase 2 (CDK2) in the protection of ginsenoside Rgl against tert-butylhydroperoxide (t-BHP)-induced senescence in WI-38 cells. 目的 探讨p21、细胞周期蛋白E(cyclin E)和周期蛋白依赖性蛋白激酶2(cyclin-dependent kinase 2,CDK2)在人参皂苷Rgl对抗三丁基过氧化氢(t-BHP)诱导’WI-38细胞衰老过程中的可能作用。
- The activity of cyclin - Cdk complexes is affected by cyclin - dependent kinase inhibitors including P27kip1. P27kIp1 protein binds to cyclin D - Cdk4, cyclin E - Cdk2 and cyclinA - Cdk2 complex inhibiting their activities during the cell cycle. 目前发现的CDKI按结构和功能的不同可分成两大类:一类为Cip/Kip(CDK-interacting protein/kinase inhibition protein),包括p21~(Cip1)、p27~(kip1)、p57~(kip2)等。