COX-2 are considered to be involved in tumor formation Studies demonstrated the effect of epidermal growth factor (EGF) on the production of PGE2 in human squamous carcinoma A431 cells.

• 研究表明，在人鳞状细胞癌A431细胞系中表皮生长因子(EGF)可使PGE2的产生增多。