CONCLUSION: P53 gene mutations was frequent in tumorigenesis of secondary GBM,and the strong mutant P53 protein expression might be related to the weak MGMT expression.

• 结论: P53基因突变是继发性GBM的发生过程中的高发事件，突变型P53蛋白的表达强度增强与MGMT表达减弱有关。